Publications – Chen Lab

Tsyporin J, Tastad D, Ma X, Nehme A, Finn T, Huebner L, Liu G, Gallardo D, Makhamreh A, Roberts JM, Katzman S, Sestan N, McConnell SK, Yang Z, Qiu S, Chen B. Transcriptional repression by FEZF2 restricts alternative identities of cortical projection neurons. Cell Rep. 2021 Jun 22;35(12):109269. doi: 10.1016/j.celrep.2021.109269. PMID: 34161768; PMCID: PMC8327856.
Zhang Y, Liu G, Guo T, Liang XG, Du H, Yang L, Bhaduri A, Li X, Xu Z, Zhang Z, Li Z, He M, Tsyporin J, Kriegstein AR, Rubenstein JL, Yang Z, Chen B. Cortical Neural Stem Cell Lineage Progression Is Regulated by Extrinsic Signaling Molecule Sonic Hedgehog. Cell Rep. 2020 Mar 31;30(13):4490-4504.e4. doi: 10.1016/j.celrep.2020.03.027. PubMed PMID: 32234482; PubMed Central PMCID: PMC7197103
Kim GB, Rincon Fernandez Pacheco D, Saxon D, Yang A, Sabet S, Dutra-Clarke M, Levy R, Watkins A, Park H, Abbasi Akhtar A, Linesch PW, Kobritz N, Chandra SS, Grausam K, Ayala-Sarmiento A, Molina J, Sedivakova K, Hoang K, Tsyporin J, Gareau DS, Filbin MG, Bannykh S, Santiskulvong C, Wang Y, Tang J, Suva ML, Chen B, Danielpour M, Breunig JJ. Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements. Cell. 2019 Sep 19;179(1):251-267.e24. doi: 10.1016/j.cell.2019.08.013. PMID: 31539496; PMCID: PMC6934691.
Liu Z, Zhang Z, Lindtner S, Li Z, Xu Z, Wei S, Liang Q, Wen Y, Tao G, You Y, Chen B, Wang Y, Rubenstein JL, Yang Z. Sp9 Regulates Medial Ganglionic Eminence-Derived Cortical Interneuron Development. Cereb Cortex. 2019 Jun 1;29(6):2653-2667. doi: 10.1093/cercor/bhy133. PubMed PMID: 29878134; PubMed Central PMCID: PMC6519701.
Cargnin F, Kwon JS, Katzman S, Chen B, Lee JW, Lee SK. FOXG1 Orchestrates Neocortical Organization and Cortico-Cortical Connections. Neuron. 2018 Dec 5;100(5):1083-1096.e5. doi: 10.1016/j.neuron.2018.10.016. Epub 2018 Nov 1. PubMed PMID: 30392794; PubMed Central PMCID: PMC6428593.
Fazel Darbandi S, Robinson Schwartz SE, Qi Q, Catta-Preta R, Pai EL, Mandell JD, Everitt A, Rubin A, Krasnoff RA, Katzman S, Tastad D, Nord AS, Willsey AJ, Chen B, State MW, Sohal VS, Rubenstein JLR. Neonatal Tbr1 Dosage Controls Cortical Layer 6 Connectivity. Neuron. 2018 Nov 21;100(4):831-845.e7. doi: 10.1016/j.neuron.2018.09.027. Epub 2018 Oct 11. PubMed PMID: 30318412; PubMed Central PMCID: PMC6250594.
Li J, Wang C, Zhang Z, Wen Y, An L, Liang Q, Xu Z, Wei S, Li W, Guo T, Liu G, Tao G, You Y, Du H, Fu Z, He M, Chen B, Campbell K, Alvarez-Buylla A, Rubenstein JL, Yang Z. Transcription Factors Sp8 and Sp9 Coordinately Regulate Olfactory Bulb Interneuron Development. Cereb Cortex. 2018 Sep 1;28(9):3278-3294. doi: 10.1093/cercor/bhx199. PubMed PMID: 28981617; PubMed Central PMCID: PMC6095218.
Xu Z, Liang Q, Song X, Zhang Z, Lindtner S, Li Z, Wen Y, Liu G, Guo T, Qi D, Wang M, Wang C, Li H, You Y, Wang X, Chen B, Feng H, Rubenstein JL, Yang Z. SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression. Development. 2018 Jul 23;145(14). doi: 10.1242/dev.165456. PubMed PMID: 29967281; PubMed Central PMCID: PMC6078334.
Liu J, Reggiani JDS, Laboulaye MA, Pandey S, Chen B, Rubenstein JLR, Krishnaswamy A, Sanes JR. Tbr1 instructs laminar patterning of retinal ganglion cell dendrites. Nat Neurosci. 2018 May;21(5):659-670. doi: 10.1038/s41593-018-0127-z. Epub 2018 Apr 9. PubMed PMID: 29632360; PubMed Central PMCID: PMC5920715.
Godbole G, Shetty AS, Roy A, D’Souza L, Chen B, Miyoshi G, Fishell G, Tole S. Hierarchical genetic interactions between FOXG1 and LHX2 regulate the formation of the cortical hem in the developing telencephalon. Development. 2018 Jan 9;145(1). doi: 10.1242/dev.154583. PubMed PMID: 29229772; PubMed Central PMCID: PMC5825872.
Mirzadeh Z, Kusne Y, Duran-Moreno M, Cabrales E, Gil-Perotin S, Ortiz C, Chen B, Garcia-Verdugo JM, Sanai N, Alvarez-Buylla A. Bi- and uniciliated ependymal cells define continuous floor-plate-derived tanycytic territories. Nat Commun. 2017 Jan 9;8:13759. doi: 10.1038/ncomms13759. PubMed PMID: 28067220; PubMed Central PMCID: PMC5477523.
Dwyer ND, Chen B, Chou SJ, Hippenmeyer S, Nguyen L, Ghashghaei HT. Neural Stem Cells to Cerebral Cortex: Emerging Mechanisms Regulating Progenitor Behavior and Productivity. J Neurosci. 2016 Nov 9;36(45):11394-11401. doi: 10.1523/JNEUROSCI.2359-16.2016. Review. PubMed PMID: 27911741; PubMed Central PMCID: PMC5125206.
Zhang Q, Zhang Y, Wang C, Xu Z, Liang Q, An L, Li J, Liu Z, You Y, He M, Mao Y, Chen B, Xiong ZQ, Rubenstein JL, Yang Z. The Zinc Finger Transcription Factor Sp9 Is Required for the Development of Striatopallidal Projection Neurons. Cell Rep. 2016 Aug 2;16(5):1431-1444. doi: 10.1016/j.celrep.2016.06.090. Epub 2016 Jul 21. PubMed PMID: 27452460; PubMed Central PMCID: PMC4972643.
Notwell JH, Heavner WE, Darbandi SF, Katzman S, McKenna WL, Ortiz-Londono CF, Tastad D, Eckler MJ, Rubenstein JL, McConnell SK, Chen B, Bejerano G. TBR1 regulates autism risk genes in the developing neocortex. Genome Res. 2016 Aug;26(8):1013-22. doi: 10.1101/gr.203612.115. Epub 2016 Jun 20. PubMed PMID: 27325115; PubMed Central PMCID: PMC4971772.
Shanks JA, Ito S, Schaevitz L, Yamada J, Chen B, Litke A, Feldheim DA. Corticothalamic Axons Are Essential for Retinal Ganglion Cell Axon Targeting to the Mouse Dorsal Lateral Geniculate Nucleus. J Neurosci. 2016 May 11;36(19):5252-63. doi: 10.1523/JNEUROSCI.4599-15.2016. PubMed PMID: 27170123; PubMed Central PMCID: PMC4863061.
McKenna WL, Ortiz-Londono CF, Mathew TK, Hoang K, Katzman S, Chen B. Mutual regulation between Satb2 and Fezf2 promotes subcerebral projection neuron identity in the developing cerebral cortex. Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11702-7. doi: 10.1073/pnas.1504144112. Epub 2015 Aug 31. PubMed PMID: 26324926; PubMed Central PMCID: PMC4577201.
Eckler MJ, Nguyen TD, McKenna WL, Fastow BL, Guo C, Rubenstein JLR, Chen B. Cux2-positive radial glial cells generate diverse subtypes of neocortical projection neurons and macroglia. Neuron. 2015 May 20;86(4):1100-1108. doi: 10.1016/j.neuron.2015.04.020. PubMed PMID: 25996137; PubMed Central PMCID: PMC4441766.
Eckler MJ, Chen B. Fez family transcription factors: controlling neurogenesis and cell fate in the developing mammalian nervous system. Bioessays. 2014 Aug;36(8):788-97. doi: 10.1002/bies.201400039. Epub 2014 Jun 10. Review. PubMed PMID: 24913420; PubMed Central PMCID: PMC5472476.
Pattabiraman K, Golonzhka O, Lindtner S, Nord AS, Taher L, Hoch R, Silberberg SN, Zhang D, Chen B, Zeng H, Pennacchio LA, Puelles L, Visel A, Rubenstein JL. Transcriptional regulation of enhancers active in protodomains of the developing cerebral cortex. Neuron. 2014 Jun 4;82(5):989-1003. doi: 10.1016/j.neuron.2014.04.014. Epub 2014 May 8. PubMed PMID: 24814534; PubMed Central PMCID: PMC4104757.
Eckler MJ, Larkin KA, McKenna WL, Katzman S, Guo C, Roque R, Visel A, Rubenstein JL, Chen B. Multiple conserved regulatory domains promote Fezf2 expression in the developing cerebral cortex. Neural Dev. 2014 Mar 12;9:6. doi: 10.1186/1749-8104-9-6. PubMed PMID: 24618363; PubMed Central PMCID: PMC4008173.
Qiu H, Lee S, Shang Y, Wang WY, Au KF, Kamiya S, Barmada SJ, Finkbeiner S, Lui H, Carlton CE, Tang AA, Oldham MC, Wang H, Shorter J, Filiano AJ, Roberson ED, Tourtellotte WG, Chen B, Tsai LH, Huang EJ. ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects. J Clin Invest. 2014 Mar;124(3):981-99. doi: 10.1172/JCI72723. Epub 2014 Feb 10. PubMed PMID: 24509083; PubMed Central PMCID: PMC3938263.
Roberts JM, Ennajdaoui H, Edmondson C, Wirth B, Sanford JR, Chen B. Splicing factor TRA2B is required for neural progenitor survival. J Comp Neurol. 2014 Feb 1;522(2):372-92. doi: 10.1002/cne.23405. PubMed PMID: 23818142; PubMed Central PMCID: PMC3855887.
Betancourt J, Katzman S, Chen B. Nuclear factor one B regulates neural stem cell differentiation and axonal projection of corticofugal neurons. J Comp Neurol. 2014 Jan 1;522(1):6-35. doi: 10.1002/cne.23373. PubMed PMID: 23749646; PubMed Central PMCID: PMC4058429.
Guo C, Eckler MJ, McKenna WL, McKinsey GL, Rubenstein JL, Chen B. Fezf2 expression identifies a multipotent progenitor for neocortical projection neurons, astrocytes, and oligodendrocytes. Neuron. 2013 Dec 4;80(5):1167-74. doi: 10.1016/j.neuron.2013.09.037. PubMed PMID: 24314728; PubMed Central PMCID: PMC3857588.
Kmet M, Guo C, Edmondson C, Chen B. Directed differentiation of human embryonic stem cells into corticofugal neurons uncovers heterogeneous Fezf2-expressing subpopulations. PLoS One. 2013;8(6):e67292. doi: 10.1371/journal.pone.0067292. Print 2013. PubMed PMID: 23826257; PubMed Central PMCID: PMC3691138.
Kumamoto T, Toma K, Gunadi, McKenna WL, Kasukawa T, Katzman S, Chen B, Hanashima C. Foxg1 coordinates the switch from nonradially to radially migrating glutamatergic subtypes in the neocortex through spatiotemporal repression. Cell Rep. 2013 Mar 28;3(3):931-45. doi: 10.1016/j.celrep.2013.02.023. Epub 2013 Mar 21. PubMed PMID: 23523356; PubMed Central PMCID: PMC3648982.
Eckler MJ, McKenna WL, Taghvaei S, McConnell SK, Chen B. Fezf1 and Fezf2 are required for olfactory development and sensory neuron identity. J Comp Neurol. 2011 Jul 1;519(10):1829-46. doi: 10.1002/cne.22596. PubMed PMID: 21452247; PubMed Central PMCID: PMC3268373.
McKenna WL, Betancourt J, Larkin KA, Abrams B, Guo C, Rubenstein JL, Chen B. Tbr1 and Fezf2 regulate alternate corticofugal neuronal identities during neocortical development. J Neurosci. 2011 Jan 12;31(2):549-64. doi: 10.1523/JNEUROSCI.4131-10.2011. PubMed PMID: 21228164; PubMed Central PMCID: PMC3276402.
Chen B, Wang SS, Hattox AM, Rayburn H, Nelson SB, McConnell SK. The Fezf2-Ctip2 genetic pathway regulates the fate choice of subcortical projection neurons in the developing cerebral cortex. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11382-7. doi: 10.1073/pnas.0804918105. Epub 2008 Aug 4. PubMed PMID: 18678899; PubMed Central PMCID: PMC2495013.
Leone DP, Srinivasan K, Chen B, Alcamo E, McConnell SK. The determination of projection neuron identity in the developing cerebral cortex. Curr Opin Neurobiol. 2008 Feb;18(1):28-35. doi: 10.1016/j.conb.2008.05.006. Epub 2008 May 26. Review. PubMed PMID: 18508260; PubMed Central PMCID: PMC2483251.
Chen B, Schaevitz LR, McConnell SK. Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex. Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17184-9. doi: 10.1073/pnas.0508732102. Epub 2005 Nov 11. PubMed PMID: 16284245; PubMed Central PMCID: PMC1282569.
Friedel RH, Plump A, Lu X, Spilker K, Jolicoeur C, Wong K, Venkatesh TR, Yaron A, Hynes M, Chen B, Okada A, McConnell SK, Rayburn H, Tessier-Lavigne M. Gene targeting using a promoterless gene trap vector (“targeted trapping”) is an efficient method to mutate a large fraction of genes. Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13188-93. doi: 10.1073/pnas.0505474102. Epub 2005 Aug 29. PubMed PMID: 16129827; PubMed Central PMCID: PMC1193537.
Chen B, Harms E, Chu T, Henrion G, Strickland S. Completion of meiosis in Drosophila oocytes requires transcriptional control by grauzone, a new zinc finger protein. Development. 2000 Mar;127(6):1243-51. PubMed PMID: 10683177.
Chen B, Chu T, Harms E, Gergen JP, Strickland S. Mapping of Drosophila mutations using site-specific male recombination. Genetics. 1998 May;149(1):157-63. PubMed PMID: 9584093; PubMed Central PMCID: PMC1460155.